Die Top 50 der 42. Kw 2021
| Rang | Punkte | Interpret/ Titel | Anhören | Tendenz | |
| 1 | 272 |  | Purple Disco Machine feat. Eyelar Dopamine (Virgin) |    |  |
| 2 | 147 |  | ATB feat. Ben Samama Like That (Universal) | | |
| 3 | 100 |  | Tom Franke Free (Acalwan) | | |
| 4 | 94 |  | DJ LXNDR x Jayde Yang 247 (Moderntune Records) | | |
| 5 | 85 |  | Alle Farben feat Kiddo Alright (Warner) | |  |
| 6 | 78 |  | Jason Derulo Acapulco (Atlantic) | | |
| 7 | 76 |  | Discodumper & Noty We Love The Night (Kommandörr Music) | |  |
| 8 | 73 |  | Aquagen O Sarracino (Mental Madness) | | |
| 9 | 70 |  | Da Clubbmaster X Tom Pulse Never Knew Love Like This Before (ZYX) | | |
| 10 | 61 |  | Claptone feat. Seal Just A Ghost (Different Records) | | |
| 11 | 59 |  | SoftTouch Moonlight Shadow (Flint Productions) | | |
| 12 | 57 |  | Joel Corry x Jax Jones feat. Charli XCX & Saweetie Out Out (Warner) | | |
| 13 | 46 |  | Felix Jaehn & Robin Schulz feat. Georgia Ku I Got A Feeling (Virgin) | | |
| 14 | 45 |  | John Bounce Fool To Your Love (ZYX) | | |
| 15 | 42 |  | Tiesto & Karol G Dont Be Shy (Warner) | | |
| 16 | 40 |  | Anticappella Move Your Body (Jason Parker Remix) (ZYX) | | |
| 17 | 36 |  | HEIN+KLEIN & Cheyenne Every Breath You Take (The Deeper Institute Recordings) | | |
| 18 | 36 |  | Talla 2XLC & Jay Frog Native American (Thats Trance) | | |
| 19 | 36 |  | Klaas Hello (Turn Your Radio On) (You Love Dance) | | |
| 20 | 35 |  | Armin van Buuren & Jorn van Deynhoven Lost In Space (Kontor) | | |
| 21 | 34 |  | DJ Marlon Kill Me With Your Love (Loudkult) | | |
| 22 | 32 |  | DJ B-Dome Sometimes (Tokabeatz) | | |
| 23 | 31 |  | Le Shuuk x Papi Pepe Macarena (Kontor) | | |
| 24 | 31 |  | MistaJam The Recipe (Kontor) | | |
| 25 | 30 |  | Clueless Upside Down (Timster & Ninth Remix) (ZYX) | | |
| 26 | 29 |  | Blaikz & Dantec feat. Renee Rose Sweet Melodie (Viventas Music) | | |
| 27 | 29 |  | DJ Antoine & Martin van Lectro Glow (Kontor) | | |
| 28 | 26 |  | Disco Culture vs. Greg & Gregory You To Me Are Everything (Culture 54) | | |
| 29 | 25 |  | Crew 7 & Blaikz Everytime We Touch (Andorfine Records) | | |
| 30 | 24 |  | We Will For Your Love (Non Stop Dancing) | |  |
| 31 | 23 |  | Annella I Only Have Now (Annella Music) | | |
| 32 | 21 |  | CK West feat. Sassi K C Song (HOT Music) | | |
| 33 | 21 |  | Nils van Zandt & Pakito Lonely (Bip Records) | | |
| 34 | 20 |  | Sickmellow & Caleidescope feat. Enzo Abballati (Inspirit Music) | | |
| 35 | 20 |  | Jenz im Glück feat. Brooklyn Bounce Old School Party (Mental Madness) | | |
| 36 | 20 |  | The Disco Boys feat. Manfred Manns Earth Band For You (Deeperlove Remix) (Kontor) | | |
| 37 | 20 |  | Leelah Sky Had Me At Hello (7Us) | | |
| 38 | 19 |  | Caspa Houzer La Loona (Tokabeatz) | | |
| 39 | 18 |  | Tito Puente Oye Como Va (Latin House Remix) (ZYX) | | |
| 40 | 17 |  | Dimitri Vegas & Like Mike feat. KSHMR, Alok & Zafrir Reunion (Free Fire 4th Anniversary Theme Song) (Smash The House) | | |
| 41 | 17 |  | Age Of love The Age Of Love (Charlotte de Witte & Enrico Sangiuliano Remix) (Diki Records) | | |
| 42 | 17 |  | Fred again.. Billie (Loving Arms) (Atlantic UK) | | |
| 43 | 16 |  | Hugel Back To Life (Warner) | | |
| 44 | 15 |  | Block & Crown Sweet Harmony (Mastermix Records) | | |
| 45 | 15 |  | Ancalima & Tom Franke Better Off Alone (ZYX) | | |
| 46 | 15 |  | Alan Walker & Georgia Ku Dont You Hold Me Down (Sony) | | |
| 47 | 15 |  | Pulsedriver & Tiscore One To Make Her Happy (Warner) | | |
| 48 | 14 |  | Kid Alina feat. Louis S. Anything With Love (Update Media) | | |
| 49 | 14 |  | Ben van Gosh Cant You See (ZYX) | | |
| 50 | 14 |  | The Disco Boys Around The World (DAZZ Remix) (WePlay) | | |